Spurs have lost 77 top-flight matches to Manchester United, eight more than they have against any other side.
Tottenham's tally of 32 Premier League defeats against United is also their most against any opponent.
Spurs won for the first time in 15 home league games against the Red Devils last season.
United have failed to score in their last two away league trips to White Hart Lane. In the Premier League, they've only failed to score in three consecutive away games against an opponent twice: Everton (three games) and Chelsea (four games).
Tottenham are aiming to go unbeaten at home for the first time in a league season since 1964-65.
They have won 13 home league matches in a row, one short of their club record run of 14 split over two seasons from January to October 1987.
They have hit the woodwork 20 times this season, more than any other club in the top flight.
Harry Kane has scored against 23 of the 25 clubs he's faced in the Premier League - he is yet to score in six appearances against Manchester United, and also against Cardiff.
Spurs have the best defensive record in the Premier League this season, having conceded just 23 goals. Their club record for fewest goals conceded in an entire league campaign is 32 in 1908-09 and 1919-20 (both in the second tier).
Teams managed by Jose Mourinho have failed to score in seven successive Premier League away games against current top-six opposition since Spurs beat his then-Chelsea side 5-3 on New Year's Day 2015. Four of the seven games have finished 0-0.
Three of Manchester United's four Premier League defeats this season have been in games played on a Sunday after a Europa League match.
They could finish outside the top three in four consecutive top-flight seasons for the first time since 1983-84 to 1986-87.
Mourinho has failed to win a league game at White Hart Lane since August 2005, drawing two and losing two during his spells at Chelsea.